Designed to dialyze. Built for cardioprotection.
- Efficient middle molecule removal
- INLINE steam sterilized
- Low rinsing volume
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High selective permeability for middle molecules
The new FX CorDiax is the most efficient dialyzer within the FX-class. The core of the FX CorDiax is the Helixone plus membrane, a targeted enhancement of the Helixone membrane. Improved fiber design allows for better sieving of middle molecules such as β2-microglobulin (β2-m) while restricting the loss of vital albumin. As increased levels of β2-m are associated with higher mortality risk, the use of FX CorDiax High-Flux dialyzers or hemodiafilters facilitate best possible therapy outcomes.
Refined membrane architecture
New production technology combined with INLINE steam sterilization allows crucial enhancements of membrane porosity, reducing flow resistance and improving transport across the membrane.
Benefit of refined membrane architecture
Significantly improved removal of middle molecules while preventing the loss of useful substances, such as serum albumin
Purity enhanced — with steam
|The benefits of INLINE steam sterilization|
|No chemical residuals||No need for gamma sterilization – high energy ionizing radiation can degrade |
and alter the material chemistry
|Low rinsing volumes||Rinsing time and volume is substantially lower compared to gamma sterilized dialyzers|
|Less rinsing – lower costs||Lower rinsing volumes mean reduced preparation costs|
Advances in fiber design allow for better removal of uremic toxins
- The fiber support region underneath the inner surface has been “opened up”, optimizing porosity and therefore also the convective filtration (“flushing”) of larger uremic toxins such as β2-microglobulin (≈ 11,800 Da) or myoglobin (≈ 17,000 Da)
- At the same time the size of the pores of the inner surface area was not increased to avoid flushing of albumin
Superior by design
Several state-of-the-art technologies have been combined to create the distinctive, functional features of FX-class dialyzers, which are refined and optimized for performance and handling:
- Design of dialyzer housing and fiber bundle for more uniform dialysate flow
- Refined blood inlet port for improved hemodynamics
Advances in material and production technologies have permitted improvements in the wall structure of the Helixoneplus membrane of the FX CorDiax.
- More porous membrane wall for higher clearance of middle molecules
|Optimized dialysate flow||The 3-dimensional microwave structure of the fiber ensures |
niform radial dialysate flow around each fiber within the
bundle by preventing fluid channeling, thereby enhancing
clearance values and improving the overall performance of
|Better hemodynamics||The lateral blood-inlet port ensures more homogenous blood |
flow in the dialyzer header, preventing stagnation zones. The
design essentially minimizes the risk of kinking, contributing
to improved safety.
|Enhanced convection||The more open structure of the Helixoneplus membrane |
support region serves to reduce diffusion resistance and
increases convective filtration. This facilitates clearance of a
broad range of uremic toxins, especially the middle molecules.
|Kind to the environment||Advanced design goes beyond direct functionality, it also has |
to be easy on the environment. FX-class dialyzers weigh half
as much as dialyzers with polycarbonate housing, and at the
same time use ecologically friendly plastics. This means a
lower carbon-footprint as a result of fewer materials, less
packaging, less fuel for transport and cleaner waste
Key to optimal middle molecule removal
Solutes encounter resistance while traversing the membrane wall. Resistance to solute transport is affected, in part, by pore size at the inner surface and the porosity of the membrane wall. Furthermore, wall structure and thickness as well as inner fiber dimensions and 3-dimensional microwave structure play important roles in transmembrane flux. The new membrane structure of Helixoneplus allows the easy passage of middle molecules across the more porous support region of the membrane.
- The structure of the support region is crucial to overall performance
- Membrane porosity, together with the pore size, regulates the transport of middle molecules
Fiber design for HD
In an HD treatment, reducing the inner fiber diameter from 200 μm (F-series) to 185 μm (FX-class) acts to increase internal filtration, thereby increasing the pressure gradient along the length of the fiber. This results in a greater pressure difference between the blood and dialysate compartments. Together with structural refinements to the support region of the fiber, this enables improvements in both diffusive and convective transport, which is of particular importance when performing High-Flux hemodialysis.
Benefit of reduced inner fiber diameter
Design of the HD fiber
- A small inner diameter of the hollow fiber increases the pressure gradient between blood and dialysate compartments
- The result is improved clearance of middle molecules such as vitamin B12, inulin, β2-microglobulin and myoglobin1
- The increased pressure gradient combined with structural refinements to the membrane (support region) enhances diffusive as well as convective filtration, especially when performing High-Flux hemodialysis with FX CorDiax
FX CorDiax hemodiafilter
HighVolumeHDF therapy requires specially designed filters. Stepping up to this challenge, FX CorDiax hemodiafilter were developed for HighVolumeHDF
Increased fiber lumen for better flow conditions
- An increase of its inner diameter results in a reduced pressure drop within a hollow fiber
- The capillary diameter of a dialyzer can affect performance and treatment quality
- The inner diameter of hemodiafilters is 210 μm compared to 185 μm of HD filters. The larger diameter facilitates improved flow conditions, allowing for higher convective volumes in an HDF treatment.2
The benefit of enlarged fiber lumen of FX CorDiax hemodiafilters
Sieving coefficients of FX CorDiax High-Flux Dialysers and Haemodiafilters
|Sieving coefficients of FX CorDiax High-Flux |
Dialysers and Haemodiafilters
|Molecular weight (Dalton)|
|Sterilisation method||INLINE steam|
|Units per box||24|
FX CorDiax High-Flux Dialysers
|FX CorDiax High-Flux Dialysers||FX CorDiax 40||FX CorDiax 50||FX CorDiax 60||FX CorDiax 80||FX CorDiax 100||FX CorDiax 120|
|Clearance (QB = 300 mL/min)||Molecular weight (Dalton)|
|Cytochrome c||12,230||48 *||76||96||111||125||136|
|Vitamin B12||1,355||96 *||144||175||190||207||213|
|Clearance (QB = 400 mL/min)|
|* Clearance (QB = 200 mL/min)|
|Ultrafiltration coeff. (mL/h x mmHg)||21||33||47||64||74||87|
|In vitro performance: QD = 500mL/min, QF = 0mL/min, T = 37°C (ISO8637). Sieving coefficients: human plasma, QBmax, QF = 0.2 x QBmax (ISO8637). Ultrafiltration coefficients: human blood (Hct 32%, protein content 6%).|
|Effective surface (m2)||0.6||1.0||1.4||1.8||2.2||2.5|
|Priming volume (mL)||32||53||74||95||116||132|
FX CorDiax Haemodiafilters
|FX CorDiax Haemodiafilters||FX CorDiax 600||FX CorDiax 800||FX CorDiax 1000|
|Clearance (QB = 300 mL/min, QF = 75 mL/min)||Molecular weight (Dalton)|
|Clearance (QB = 400 mL/min, QF = 100 mL/min)|
|Ultrafiltration coeff. (mL/h x mmHg)|
|In vitro performance: QD = 500 mL/min, T = 37°C (ISO8637). Sieving coefficients: human plasma, QBmax, QF = 0.2 x QBmax (ISO8637). Ultrafiltration coefficients: human blood (Hct 32%, protein content 6%).|
|Effective surface (m2)||1.6||2.0||2.3|
|Priming volume (mL)||95||115||136|
FX CorDiax has a high middle molecule removal capacity
Maduell et al. determined the removal capacity of FX CorDiax 60 compared to FX 60 in HDF postdilution treatments. Significantly higher removal rates were observed with FX CorDiax for:
Urea (60 Da)
β2-microglobulin (11.8 kDa)
Myoglobin (17.2 kDa)
Prolactin (22.9 kDa)
α1-microglobulin (33 kDa)
The authors concluded that “… treating patients with online hemodiafiltration and FX CorDiax 60 instead of FX 60 dialyzers results in significantly increased reduction ratios of middle sized molecules without clinically relevant changes in albumin loss.”
“… treating patients with online hemodiafiltration and FX CorDiax 60 instead of FX 60 dialyzers results in significantly increased reduction ratios of middle sized molecules without clinically relevant changes in albumin loss.”
In a postdilution HDF treatment the use of FX CorDiax 100 dialyzers resulted in a significantly higher clearance of β2-microglobulin than FX 100 and Polyflux 210H dialyzers. The albumin loss was low and similar for all dialysers.4
Comparison of albumin loss in a post-dilution HDF treatment
(QB = 350 mL/min, QD = 800 mL/min, QS = 80 mL/min)4
|Albumin loss (g/4h)|
|FX CorDiax 100||1.74 ± 1.01|
|FX 100||2.10 ± 1.00|
|Polyflux 21 OH||1.31 ± 0.12|
Phosphate clearance of FX CorDiax dialyzers
Comparison of aqueous in-vitro clearances of phosphate (QB = 300 mL/min, QD = 500 mL/min). Investigations carried out by EXcorLab GmbH, an Accredited Calibration and Testing Laboratory.
1 Dellanna F. et al., (1996); Nephrology Dialysis Transplantation 11 (Suppl 2): 83-86.
2 Vega Vega O. et.al.; ERA-EDTA Congress 2012, Poster 457—FP.
3 Maduell et. al.; ERA-EDTA Congress 2013, May 20, Poster Number MP 390.
4 Bock A. et al., Journal of the American Society of Nephrology (2013); 24: SA-PO404.